Blood schizontocidal activity of methylene blue in combination with antimalarials againstPlasmodium falciparum
Identifieur interne : 001A47 ( Main/Exploration ); précédent : 001A46; suivant : 001A48Blood schizontocidal activity of methylene blue in combination with antimalarials againstPlasmodium falciparum
Auteurs : Giovanny Garavito [France] ; Stephane Bertani [France] ; Javier Rincon [Colombie] ; Séverine Maurel [France] ; Marie-Carmen Monje [France] ; Irene Landau [France] ; Alexis Valentin [France] ; Eric Deharo [France]Source :
- Parasite [ 1776-1042 ] ; 2007-06-15.
English descriptors
Abstract
Methylene blue (MB) is the oldest synthetic antimalarial. It is not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive and resistant Plasmodium strains. We showed that around 5 nM of MB were able to inhibit 50% of the parasite growth in vitro and that late rings and early trophozoites were the most sensitive stages; while early rings, late trophozoites and schizonts were less sensitive. Drug interaction study following fractional inhibitory concentrations (FIC) method showed antagonism with amodiaquine, atovaquone, doxycycline, pyrimethamine; additivity with artemether, chloroquine, mefloquine, primaquine and synergy with quinine. These results confirmed the interest of MB that could be integrated in a new low cost antimalarial combination therapy.
Url:
DOI: 10.1051/parasite/2007142135
Affiliations:
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- to stream Hal, to step Checkpoint: 000221
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Le document en format XML
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last="Deharo">Eric Deharo</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-192672" status="VALID"> <idno type="ISNI">0000 0004 0490 5384</idno> <idno type="RNSR">200317398C</idno> <orgName>Pharmacochimie et Biologie pour le Développement</orgName> <orgName type="acronym">PHARMA-DEV</orgName> <date type="start">2003-01-01</date> <desc> <address> <addrLine>IRD UMR 152 Université Paul Sabatier 35 Chemin des Maraîchers 31400 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.pharmadev.ird.fr/</ref> </desc> <listRelation> <relation name="UMR152" active="#struct-67872" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="indirect"></relation> <relation 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type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-448187" type="indirect"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1051/parasite/2007142135</idno><series><title level="j">Parasite</title><idno type="ISSN">1776-1042</idno><imprint><date type="datePub">2007-06-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antimalarials</term><term>Drug interactions</term><term>Methylene blue</term><term>Plasmodium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Methylene blue (MB) is the oldest synthetic antimalarial. It is not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive and resistant Plasmodium strains. We showed that around 5 nM of MB were able to inhibit 50% of the parasite growth in vitro and that late rings and early trophozoites were the most sensitive stages; while early rings, late trophozoites and schizonts were less sensitive. Drug interaction study following fractional inhibitory concentrations (FIC) method showed antagonism with amodiaquine, atovaquone, doxycycline, pyrimethamine; additivity with artemether, chloroquine, mefloquine, primaquine and synergy with quinine. These results confirmed the interest of MB that could be integrated in a new low cost antimalarial combination therapy.</p> </div></front></TEI><affiliations><list><country><li>Colombie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Garavito, Giovanny" sort="Garavito, Giovanny" uniqKey="Garavito G" first="Giovanny" last="Garavito">Giovanny Garavito</name></noRegion><name sortKey="Bertani, Stephane" sort="Bertani, Stephane" uniqKey="Bertani S" first="Stephane" last="Bertani">Stephane Bertani</name><name sortKey="Deharo, Eric" sort="Deharo, Eric" uniqKey="Deharo E" first="Eric" last="Deharo">Eric Deharo</name><name sortKey="Landau, Irene" sort="Landau, Irene" uniqKey="Landau I" first="Irene" last="Landau">Irene Landau</name><name sortKey="Maurel, Severine" sort="Maurel, Severine" uniqKey="Maurel S" first="Séverine" last="Maurel">Séverine Maurel</name><name sortKey="Monje, Marie Carmen" sort="Monje, Marie Carmen" uniqKey="Monje M" first="Marie-Carmen" last="Monje">Marie-Carmen Monje</name><name sortKey="Valentin, Alexis" sort="Valentin, Alexis" uniqKey="Valentin A" first="Alexis" last="Valentin">Alexis Valentin</name></country><country name="Colombie"><noRegion><name sortKey="Rincon, Javier" sort="Rincon, Javier" uniqKey="Rincon J" first="Javier" last="Rincon">Javier Rincon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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